• Data (genomic sequences, 3D structures, 2D gel analysis, MS analysis, Microarrays….) are no longer published in a conventional manner, but directly submitted to databases. • Essential tools for biological research. Biological databases constitute the data layer of molecular biology and bioinformatics and are becoming a central component of some emerging fields such as clinical bioinformatics, and translational and personalized medicine. A biological database is a collection of data that is organized so that its contents can easily be accessed, managed, and updated. Biological databases offer access to a wide variety of biological data and play a central role in bioinformatics56 7. Biological databases play a central role in bioinformatics. Originally they were just sequence collections, but they have grown to store different biological databases heavily interconnected and they provide powerful interfaces to search and browse the stored information. Statistical analysis of the data is central to this assessment. The distinction between the concepts of biological relevance and statistical significance should be EMBnet MCB, feb 2005 Distribution of databases Bioinformatics is the branch of science in which we use computer tools and algorithms to analyze biological data. They offer scientists the opportunity to access sequence and structure data for tens of thousands of sequences from a broad range of organisms. Law enforcement agencies use these databases to track collected evidence. An important resource for finding biological databases is a special yearly issue of the journal Nucleic Acids Research (NAR). Confusion in the use of words such as “significance”, “relevance” and “importance” can therefore hinder the assessment. Bioinformatics has its importance in the management and collection of biological data. Its mission is to make life science research more efficient and reproducible by curating and hosting high-quality, experimentally validated, freely accessible protocols. Bio-101 is an online database of life science protocols. Bioinformatics is an integrated interdisciplinary field it includes various subjects such as math, chemistry, genomics, proteomics, etc. Baxevanis AD. A protein database is one or more datasets about proteins, which could include a protein’s amino acid sequence, conformation, structure, and … They offer scientists the opportunity to access a wide variety of biologically relevant data, including the genomic sequences of an increasingly broad range of organisms. Biological databases play a central role in bioinformatics. INTRODUCTION TO BIOLOGICAL DATABASES SARFARAZ HUSSAIN Department of Bioinformatics & Biotechnology GCU- Faisalabad NOTE: Most slides derived from NCBI’s field guide / sarfraz1412@gmail.com 2. Biological databases 1. 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