We describe here the effects of treatment with interferon (IFN)-α2b in a cohort of confirmed COVID-19 cases in Wuhan, China. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. 3. These cells are usually challenged with EMCV. Interféron alpha. Besremi ropeginterféron alfa-2b - PEGASYS Peginterféron alfa-2a - Antiviraux utilisés dans les hépatites virales - ROFERON-A - PEGASYS - PEGASYS 90 microgrammes, solution injectable en seringue préremplie - Peg-interféron alpha-2a versus peg-interféron alpha-2b pour l'hépatite C chronique - PEGASYS 135 µg, solution injectable en seringue préremplie - PEGASYS 135 … Interferon was named for its ability to interfere with viral proliferation. Was named interferon alpha-E (embryonic) based on peptide sequencing (PubMed:9244179). Produced by macrophages, IFN-alpha have antiviral activities. Increased levels suggest recent or ongoing viral or parasitic infection. Many researchers will use the human lung carcinoma cell line A549 due to their ease of growth and relatively high sensitivity to all forms of human interferons. Interferon therapy is associated with significant side effects, including flulike syndrome, fever, depression, insomnia, irritability, and bone marrow suppression (see Chapter 16). Interferon alpha (IFN-α) is a glycoprotein with antitumor, antiviral, and immunomodulatory activity, used widely in the treatment of viral infections (hepatitis B and C, condylomata acuminata, herpes zoster, etc. The pleiotropic cytokine interferon alpha is involved in multiple aspects of lupus etiology and pathogenesis. Interferon alpha, like all interferons has a variable and broad-spectrum antiviral effects. n. 1. - L’interféron alpha L’interféron alpha, molécule physiologique associe des propriétés antivirales, immuno-modulatrices et antiprolifératives. Également diponible, lié de manière covalente au monométhoxy polyéthylène glycol (PEG) (à avoir, le peginterféron alfa). Remerciements Aux membres du jury , Monsieur le Professeur Gilles DUVERLIE Professeur des Universités – Praticien Hospitalier Chef du Service de Virologie du CHU d’Amiens Doyen de la Faculté de Pharmacie Directeur de l’Unité de Virologie UVCF EA4294 Je vous remercie de m’avoir accueillie dans votre laboratoire, de m’avoir … Author summary Innate immune responses contribute to the control of viral infections and the induction of interferon alpha (IFNα)-mediated antiviral responses is an important component. However, IFNα induces a multitude of antiviral response genes and the expression dynamics of these genes can be classified as early, intermediate and late. En attendant d'autres anti-viraux, le renforcement du traitement par l'interféron est une option pour augmenter les chances de réponse virologique (3). Les interférons pégylés (format PDF) La bithérapie par interféron et ribavirine est actuellement le traitement de référence de l’hépatite chronique C (1,2), mais 60 % des malades ne répondent pas ou rechutent après le traitement. The interferon-induced flare of hepatitis may be severe and is particularly dangerous in patients with advanced liver disease and cirrhosis, who may not be able to tolerate a flare of hepatitis. HALLMARK_INTERFERON_ALPHA_RESPONSE: Systematic name: M5911: Brief description: Genes up-regulated in response to alpha interferon proteins. L'interféron alpha est le seul agent agréé pour le traitement d'appoint postopératoire du mélanome cutané à haut risque. The global pandemic of COVID-19 cases caused by infection with SARS-CoV-2 is ongoing, with no approved antiviral intervention. A comparison of interferon-Con1 with natural recombinant interferons-alpha: antiviral, antiproliferative, and natural killer-inducing activities. Bien que le mode d'action antiviral exact de l'interféron alfa-2b recombinant ne soit pas connu, il semble modifier le métabolisme de la cellule hôte. Essentially, when confronted with a virus, each cell shoots an emergency flare of interferon to tell the immune system to marshall its defenses. Human interferon alpha (hIFN) is a wide biological activity cytokine that is used in hepatitis and cancer treatments.It regulates many genes that are involved in antiviral and antiproliferative activities. This cell line is sensitive to alpha, beta and gamma interferon. The study provides no information about the effect of interferon beta-1b when administered ≥7 days after symptom onset. The diverse biological activities of the IFN-alpha's are conveyed to cells through specific interactions with cell-surface receptors. There is an urgent need to identify antivirals to curtail the COVID-19 pandemic. However, heightened levels of serum interferon alpha and expression of interferon response genes are common in lupus patients. The differences found may be sequencing erros and have not been confirmed by other studies. L'interféron alpha est produit par les leucocytes, c'est-à-dire les globules blancs. Although interferon alpha (IFN-alpha) is known to suppress viral DNA replication by affecting its basal promoter activation process, it is rarely used in CAEBV patients. Glenn Francis Browning, Editor. Diponible en Amérique ou le nom d'interféron alfa-2b et d'interféron alfa-n3. The human alpha-interferon (huIFN-alpha) family displays broad spectrum antiviral, antiproliferative and immunomodulatory activities on a variety of cell types. Il permet l’établissement rapide d’un état antiviral cellulaire via l’induction de facteurs cellulaires antiviraux et participe à l’initiation de la réponse immunitaire innée. Leur nom d'interféron vient du fait qu'ils interfèrent avec la réplication virale dans les cellules de l'hôte, en activant des cellules NK et les macrophages et en améliorant la résistance des Outre son action antivirale, l'interféron peut modifier certaines réactions immunologiques et s'opposer au développement de cellules normales ou anormales. Interferon, any of several related proteins that are produced by the body’s cells as a defensive response to viruses. Interferon Alpha (Interferon Alfa) Interferons (INFs) are naturally occurring glycoprotein cytokines that inhibit viral replication. Les interférons (IFN) sont les principales cytokines synthétisées par les cellules du système immunitaire lors de la détection d’un virus. Herein, we report the sensitivity of SARS-CoV-2 to recombinant human interferons α and β (IFNα/β). 1 Publication , , , Caution. The various forms of interferon are the body’s most Full description or abstract : Collection: H: hallmark gene sets: Source publication : Exact source : Related gene sets (show 82 founder gene sets for this hallmark gene set) Pré-analytique. Le traitement d'appoint à l'interféron n'est donc pas universellement considéré comme un traitement de référence par tous les oncologues. alpha-interferon synonyms, alpha-interferon pronunciation, alpha-interferon translation, English dictionary definition of alpha-interferon. Natural interferons are produced by lymphocytes as part of an immunological response to viral antigens. Interferon beta-1a, currently in use to treat multiple sclerosis, and interferon alfa-2b are both under investigation as potential treatments for people with COVID-19 coronavirus disease, the deadly respiratory pandemic caused by the SARS-nCoV-2 virus.. Define alpha-interferon. Interferons appear to be effective at slowing the replication of almost any human virus. For the measurement of human interferon a wider variety of systems are used. EFFET ANTIVIRAL DES INTERFÉRONS SUR LE VIRUS BK . L'interféron de type I (alpha ou bêta) est une substance antivirale codée par un gène situé sur le chromosome 9. Interferon alpha as antiviral therapy in chronic active Epstein-Barr virus disease with interstitial pneumonia - case report BMC Infect Dis. Interferon-a (a family of about 20 related proteins) and interferon-b are particularly potent as antiviral agents. J Interferon Res. IFNalpha shows antiviral, antiparasitic, and antiproliferative properties. L'interféron alfa et une famille de protéine et de glycoprotéine ayant de activité antivirale, antinéoplaique et immunomodulatrice. Interferon-alpha synonyms, Interferon-alpha pronunciation, Interferon-alpha translation, English dictionary definition of Interferon-alpha. L'interféron de type II (gamma) est codé pr un gène situé sur le chromosome 12. Ils le font en induisant la production de protéines de la fonction immunitaire (notamment antivirales et anti-bactériennes, ou à effet sur la réponse immune, et à visée anti-prolifératives). Interferon-alpha - IFNalpha is mainly produced by monocytes/macrophages, lymphoblastic cells and fibroblasts, but different types of virus activated cells may produce the cytokine. The antiviral and clinical effect was more pronounced in the patients hospitalized within 7 days of symptom onset, suggesting that interferon beta-1b with or without ribavirin was the critical component of the combination antiviral therapy. However, its clinical efficacy is decreased by the serious side effects. Interferon Alfa-2b. Interferon-alpha (leukocyte interferon) is produced by virus-infected leukocytes, etc. Abstract. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. [ PubMed ] L'interféron alpha est utilisé comme marqueur précoce des méningoencéphalites virales où il est souvent présent pendant 10 jours dès le début des signes cliniques. Expression of Intracellular Interferon-Alpha Confers Antiviral Properties in Transfected Bovine Fetal Fibroblasts and Does Not Affect the Full Development of SCNT Embryos. L'interféron alfa-2b recombinant inhibe également la réplication virale in vitro et in vivo. Cette action inhibe la réplication virale ou, … A 22-year-old Caucasian woman, diagnosed with CAEBV 1.5 years earlier, was admitted to the Immunology Clinic due to a 4-week history of productive cough, fever and general weakness. Il existe plusieurs interférons: - les interférons de type I qui sont l'interféron alpha et béta. 2018 Apr 20;18(1):190. doi: 10.1186/s12879-018-3097-6. L’interféron α, obtenu par génie génétique, est utilisé comme antinéoplasique et comme antiviral : Antinéoplasique : traitement de la leucémie à tricholeucocytes de la leucémie myéloïde chronique, du mélanome malin disséminé, du sarcome de Kaposi, du cancer du rein métastatique. Dawei Yu, 1, 3 Shoufeng Zhang, 2 Weihua Du, 1, * Jinxia Zhang, 2 Zongxing Fan, 1 Haisheng Hao, 1 Yan Liu, 1 Xueming Zhao, 1 Tong Qin, 1 and Huabin Zhu 1. Toutefois, l'avantage de survie associé à ce traitement est incertain, en particulier en termes de survie globale. 1992; 12 :55–59. Produced by macrophages, IFN-alpha have antiviral activities. Interferon-beta (fibroblast interferon) is produced by virus-infected fibroblasts, or virus-infected epithelial cells, etc . L'interféron alpha recombinant est utilisé en thérapie antivirale (hépatites B et C, Kaposi, au cours du SIDA) mais aussi en thérapie anti-cancéreuse. They are important modulators of the immune response. 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